The 22-year-old Querrey has yet to reach the last eight of a Grand Slam event, however he is currently enjoying his best season.
So far the American has picked up ATP titles this year, including his success at Queen's leading up to Wimbledon.
And Murray knows exactly where the 18th seed's strengths lie.
It will be a tough match. He's obviously won Queen's and he's a very good player," said Murray, who has won all three of the previous meetings with Querrey.
"He's got a big serve, bigger than the guys that I've played so far, and a slightly more unpredictable game.
"But I've played well against him in the past, he's someone I've had good success against. Hopefully I can get another good result."
Murray arrived at Wimbledon having endured a disappointing slump in form. But a run of impressive wins at the All England Club have revived hopes that Murray can go all the way.
However the 23-year-old Scot insists that he still has to improve if he is to win the title.
"The start's been very good and something that I needed for the confidence," added Murray.
"But I did feel I wasn't too far away from playing very good tennis again. I just needed to put more work in, and I did that the week before. So that definitely helped me going into the tournament with my belief.
"It's obviously showed in the first few matches. But I'm going to have to play better if I want to go all the way."